Dual Regulation of Neuronal Morphogenesis by a Delta-catenin-cortactin Complex and Rho

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2003 Jul 2

PMID 12835311

Citations 56

Authors

Maria Cruz Martinez

Tomoyo Ochiishi

Michael Majewski

Kenneth S Kosik

Affiliations

Soon will be listed here.

Abstract

Delta-catenin is a neuronal protein that contains 10 Armadillo motifs and binds to the juxtamembrane segment of classical cadherins. We report that delta-catenin interacts with cortactin in a tyrosine phosphorylation-dependent manner. This interaction occurs within a region of the delta-catenin sequence that is also essential for the neurite elongation effects. Src family kinases can phosphorylate delta-catenin and bind to delta-catenin through its polyproline tract. Under conditions when tyrosine phosphorylation is reduced, delta-catenin binds to cortactin and cells extend unbranched primary processes. Conversely, increasing tyrosine phosphorylation disrupts the delta-catenin-cortactin complex. When RhoA is inhibited, delta-catenin enhances the effects of Rho inhibition on branching. We conclude that delta-catenin contributes to setting a balance between neurite elongation and branching in the elaboration of a complex dendritic tree.

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