Effect of the Antioxidant Mesna (2-mercaptoethane Sulfonate) on Experimental Colitis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2003 Jun 26

PMID 12822882

Citations 10

Authors

T Shusterman

S Sela

H Cohen

B Kristal

W Sbeit

R Reshef

Affiliations

Soon will be listed here.

Abstract

Reactive oxygen species play a key role in intestinal inflammation, although interventional studies using antioxidants have shown only weak beneficial effects both in humans and animals. Hence, our aim was to examine the possible beneficial effect of the antioxidant 2-mercaptoethane sulfonate (Mesna) on experimental colitis. Colitis was induced in rats by intrarectal instillation of trinitrobenzene sulfonic acid (TNB) followed immediately by intrarectal Mesna or saline, administered for 14 days, twice daily. A beneficial effect of Mesna was observed, resulting in a significant reduction in inflammation followed by almost full recovery. iNOS mRNA expression and myeloperoxidase (MPO) activity were significantly increased in the TNB-Mesna group. These results suggest that the induction of iNOS in the presence of Mesna reduced intestinal inflammation. Mesna probably resolved this inflammation by scavenging reactive oxygen species generated by the augmented infiltration of polymorphonuclear leukocytes.

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