MRNA Cap-1 Methyltransferase in the SARS Genome

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2003 Jun 18

PMID 12809601

Citations 80

Authors

Marcin von Grotthuss

Lucjan S Wyrwicz

Leszek Rychlewski

Affiliations

Soon will be listed here.

Abstract

The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.

Citing Articles

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases.

Samrat S, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X Emerg Microbes Infect. 2023; 12(1):2204164.

PMID: 37060263 PMC: 10165934. DOI: 10.1080/22221751.2023.2204164.

Pancolitis Associated With COVID-19 Infection: A Case Report.

Hussien S, Tewoldemedhin B, Tran D, Sood A, Micheal M Cureus. 2022; 13(12):e20307.

PMID: 35028209 PMC: 8747971. DOI: 10.7759/cureus.20307.

Coronaviral RNA-methyltransferases: function, structure and inhibition.

Nencka R, Silhan J, Klima M, Otava T, Kocek H, Krafcikova P Nucleic Acids Res. 2022; 50(2):635-650.

PMID: 35018474 PMC: 8789044. DOI: 10.1093/nar/gkab1279.

Antiviral Activity of Ribavirin against in Fish Cells.

Lertwanakarn T, Trongwongsa P, Yingsakmongkol S, Khemthong M, Tattiyapong P, Surachetpong W Pathogens. 2021; 10(12).

PMID: 34959571 PMC: 8705004. DOI: 10.3390/pathogens10121616.

Innate Immunity Evasion Strategies of Highly Pathogenic Coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2.

Li J, Zhou Z, Wang Q, He Q, Zhao M, Qiu Y Front Microbiol. 2021; 12:770656.

PMID: 34777324 PMC: 8586461. DOI: 10.3389/fmicb.2021.770656.

References

Wu X, Guarino L . Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2'-O)-methyltransferase. J Virol. 2003; 77(6):3430-40. PMC: 149537. DOI: 10.1128/jvi.77.6.3430-3440.2003. View

Vlot A, Menard A, Bol J . Role of the alfalfa mosaic virus methyltransferase-like domain in negative-strand RNA synthesis. J Virol. 2002; 76(22):11321-8. PMC: 136773. DOI: 10.1128/jvi.76.22.11321-11328.2002. View

Woyciniuk P, Linder M, Scholtissek C . The methyltransferase inhibitor Neplanocin A interferes with influenza virus replication by a mechanism different from that of 3-deazaadenosine. Virus Res. 1995; 35(1):91-9. DOI: 10.1016/0168-1702(94)00085-q. View

Bray M, Raymond J, Geisbert T, Baker R . 3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice. Antiviral Res. 2002; 55(1):151-9. DOI: 10.1016/s0166-3542(02)00018-9. View

Ginalski K, Elofsson A, Fischer D, Rychlewski L . 3D-Jury: a simple approach to improve protein structure predictions. Bioinformatics. 2003; 19(8):1015-8. DOI: 10.1093/bioinformatics/btg124. View

Feder M, Pas J, Wyrwicz L, Bujnicki J . Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Gene. 2003; 302(1-2):129-38. DOI: 10.1016/s0378-1119(02)01097-1. View

De Clercq E . Carbocyclic adenosine analogues as S-adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advances. Nucleosides Nucleotides. 1998; 17(1-3):625-34. DOI: 10.1080/07328319808005205. View

Marchler-Bauer A, Anderson J, DeWeese-Scott C, Fedorova N, Geer L, He S . CDD: a curated Entrez database of conserved domain alignments. Nucleic Acids Res. 2003; 31(1):383-7. PMC: 165534. DOI: 10.1093/nar/gkg087. View

Bujnicki J, Rychlewski L . Reassignment of specificities of two cap methyltransferase domains in the reovirus lambda 2 protein. Genome Biol. 2001; 2(9):RESEARCH0038. PMC: 56899. DOI: 10.1186/gb-2001-2-9-research0038. View

10.

Reinisch K, Nibert M, Harrison S . Structure of the reovirus core at 3.6 A resolution. Nature. 2000; 404(6781):960-7. DOI: 10.1038/35010041. View

11.

Bach C, Cramer A, Scholtissek C . Effect of methyltransferase inhibitors on the regulation of baculovirus protein synthesis. J Gen Virol. 1995; 76 ( Pt 4):1025-32. DOI: 10.1099/0022-1317-76-4-1025. View

12.

Latner D, Thompson J, Gershon P, Storrs C, Condit R . The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions. Virology. 2002; 301(1):64-80. DOI: 10.1006/viro.2002.1538. View