Red Blood Cell Rheology in Sepsis

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 2003 Jun 13

PMID 12802488

Citations 55

Authors

M Piagnerelli

K Zouaoui Boudjeltia

M Vanhaeverbeek

J-L Vincent

Affiliations

Soon will be listed here.

Abstract

Changes in red blood cell (RBC) function can contribute to alterations in microcirculatory blood flow and cellular dysoxia in sepsis. Decreases in RBC and neutrophil deformability impair the passage of these cells through the microcirculation. While the role of leukocytes has been the focus of many studies in sepsis, the role of erythrocyte rheological alterations in this syndrome has only recently been investigated. RBC rheology can be influenced by many factors, including alterations in intracellular calcium and adenosine triphosphate (ATP) concentrations, the effects of nitric oxide, a decrease in some RBC membrane components such as sialic acid, and an increase in others such as 2,3 diphosphoglycerate. Other factors include interactions with white blood cells and their products (reactive oxygen species), or the effects of temperature variations. Understanding the mechanisms of altered RBC rheology in sepsis, and the effects on blood flow and oxygen transport, may lead to improved patient management and reductions in morbidity and mortality.

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References

Voerman H, Fonk T, Thijs L . Changes in hemorheology in patients with sepsis or septic shock. Circ Shock. 1989; 29(3):219-27. View

Todd 3rd J, Mollitt D . Leukocyte modulation inhibits endotoxin-induced disruption of intracellular calcium homeostasis. J Trauma. 1995; 39(6):1148-51; discussion 1151-2. DOI: 10.1097/00005373-199512000-00024. View

Mohandas N, Chasis J, SHOHET S . The influence of membrane skeleton on red cell deformability, membrane material properties, and shape. Semin Hematol. 1983; 20(3):225-42. View

Hurd T, Dasmahapatra K, RUSH Jr B, Machiedo G . Red blood cell deformability in human and experimental sepsis. Arch Surg. 1988; 123(2):217-20. DOI: 10.1001/archsurg.1988.01400260101012. View

Shiga T, Sekiya M, Maeda N, Kon K, Okazaki M . Cell age-dependent changes in deformability and calcium accumulation of human erythrocytes. Biochim Biophys Acta. 1985; 814(2):289-99. DOI: 10.1016/0005-2736(85)90447-x. View

Singh M, Stoltz J . Influence of temperature variation from 5 degrees C to 37 degrees C on aggregation and deformability of erythrocytes. Clin Hemorheol Microcirc. 2002; 26(1):1-7. View

Tyml K, Yu J, McCormack D . Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis. J Appl Physiol (1985). 1998; 84(3):837-44. DOI: 10.1152/jappl.1998.84.3.837. View

Drost E, Kassabian G, Meiselman H, Gelmont D, Fisher T . Increased rigidity and priming of polymorphonuclear leukocytes in sepsis. Am J Respir Crit Care Med. 1999; 159(6):1696-702. DOI: 10.1164/ajrccm.159.6.9803061. View

Voerman H, Groeneveld A . Blood viscosity and circulatory shock. Intensive Care Med. 1989; 15(2):72-8. DOI: 10.1007/BF00295980. View

10.

Vincent J, Zhang H, Szabo C, Preiser J . Effects of nitric oxide in septic shock. Am J Respir Crit Care Med. 2000; 161(6):1781-5. DOI: 10.1164/ajrccm.161.6.9812004. View

11.

Baskurt O, Temiz A, Meiselman H . Red blood cell aggregation in experimental sepsis. J Lab Clin Med. 1997; 130(2):183-90. DOI: 10.1016/s0022-2143(97)90094-9. View

12.

Todd 3rd J, Mollitt D . Effect of sepsis on erythrocyte intracellular calcium homeostasis. Crit Care Med. 1995; 23(3):459-65. DOI: 10.1097/00003246-199503000-00008. View

13.

Bergfeld G, Forrester T . Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res. 1992; 26(1):40-7. DOI: 10.1093/cvr/26.1.40. View

14.

Chung T, ORear E, Whitsett T, Hinshaw L, Smith M . Survival factors in a canine septic shock model. Circ Shock. 1991; 33(3):178-82. View

15.

Lux S . Dissecting the red cell membrane skeleton. Nature. 1979; 281(5731):426-9. DOI: 10.1038/281426a0. View

16.

Powell R, Machiedo G, RUSH Jr B . Decreased red blood cell deformability and impaired oxygen utilization during human sepsis. Am Surg. 1993; 59(1):65-8. View

17.

Sowemimo-Coker S, Debbas N, Kovacs I, Turner P . Ex vivo effects of nifedipine, nisoldipine and nitrendipine on filterability of red blood cells from healthy volunteers. Br J Clin Pharmacol. 1985; 20(2):152-4. PMC: 1400681. DOI: 10.1111/j.1365-2125.1985.tb05048.x. View

18.

Berliner A, Shapira I, Rogowski O, Sadees N, Rotstein R, Fusman R . Combined leukocyte and erythrocyte aggregation in the peripheral venous blood during sepsis. An indication of commonly shared adhesive protein(s). Int J Clin Lab Res. 2000; 30(1):27-31. DOI: 10.1007/s005990070030. View

19.

Goode H, Webster N . Free radicals and antioxidants in sepsis. Crit Care Med. 1993; 21(11):1770-6. DOI: 10.1097/00003246-199311000-00029. View

20.

Mallozzi C, Di Stasi A, Minetti M . Peroxynitrite modulates tyrosine-dependent signal transduction pathway of human erythrocyte band 3. FASEB J. 1997; 11(14):1281-90. DOI: 10.1096/fasebj.11.14.9409547. View