Multivariate Analysis of Risk Factors for QT Prolongation Following Subarachnoid Hemorrhage

Overview

Journal Crit Care

Specialty Critical Care

Date 2003 Jun 10

PMID 12793884

Citations 29

Authors

Shinji Fukui

Hiroshi Katoh

Nobusuke Tsuzuki

Shoichiro Ishihara

Naoki Otani

Hidetoshi Ooigawa

Terushige Toyooka

Akira Ohnuki

Takahito Miyazawa

Hiroshi Nawashiro

Katsuji Shima

Affiliations

Soon will be listed here.

Abstract

Background: Subarachnoid hemorrhage (SAH) often causes a prolongation of the corrected QT (QTc) interval during the acute phase. The aim of the present study was to examine independent risk factors for QTc prolongation in patients with SAH by means of multivariate analysis.

Method: We studied 100 patients who were admitted within 24 hours after onset of SAH. Standard 12-lead electrocardiography (ECG) was performed immediately after admission. QT intervals were measured from the ECG and were corrected for heart rate using the Bazett formula. We measured serum levels of sodium, potassium, calcium, adrenaline (epinephrine), noradrenaline (norepinephrine), dopamine, antidiuretic hormone, and glucose.

Results: The average QTc interval was 466 +/- 46 ms. Patients were categorized into two groups based on the QTc interval, with a cutoff line of 470 ms. Univariate analyses showed significant relations between categories of QTc interval, and sex and serum concentrations of potassium, calcium, or glucose. Multivariate analyses showed that female sex and hypokalemia were independent risk factors for severe QTc prolongation. Hypokalemia (<3.5 mmol/l) was associated with a relative risk of 4.53 for severe QTc prolongation as compared with normokalemia, while the relative risk associated with female sex was 4.45 as compared with male sex. There was a significant inverse correlation between serum potassium levels and QTc intervals among female patients.

Conclusion: These findings suggest that female sex and hypokalemia are independent risk factors for severe QTc prolongation in patients with SAH.

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