Bench-to-bedside Review: Severe Lactic Acidosis in HIV Patients Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors

Overview

Journal Crit Care

Specialty Critical Care

Date 2003 Jun 10

PMID 12793872

Citations 16

Authors

Yann-Erick Claessens

Jean-Daniel Chiche

Jean-Paul Mira

Alain Cariou

Affiliations

Soon will be listed here.

Abstract

Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis. In the present review, we describe the underlying mechanism of NRTI-induced toxicity and the main clinical features of this infrequent, but severe, emerging complication. We also summarise experimental data and clinical observations that support the use of L-carnitine supplementation to reverse NRTI-induced mitochondrial impairment.

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