The Effect of Leishmania Tropica on Stimulation of Lymphocytes with Phytohaemagglutinin

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1976 May 1

PMID 1278934

Citations 4

Authors

F S Farah

S Lazary

A De Weck

Affiliations

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Abstract

Cell-mediated immune (CMI) responses are important in the immunity against leishmanial infections. However, infection persists in the presence of CMI for unknown reasons. Evidence is presented that L. tropica and its products are capable of inhibition of the stimulation of lymphocytes by PHA. This inhibition is dose dependent, and not dependent on competition for nutrients in the medium, nor on neutralization of PHA. The inhibition is observed on the lymphocytes of species susceptible to leishmanial infection, and not operative in resistant species. The mechanisms of the lymphocyte suppression are discussed.

Citing Articles

[Dynamics of splenic lymphocytes and immunosuppression in Toxoplasma infected mice (author's transl)].

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Serum protein from Leishmania brasiliensis infected hamster that suppress lymphocyte response of normal hamster lymphocytes.

ODaly J, Cabrera Z Z Parasitenkd. 1986; 72(3):293-8.

PMID: 3716539 DOI: 10.1007/BF00928738.

In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin.

Bjune G Clin Exp Immunol. 1979; 36(3):479-87.

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In vitro suppression of lymphocyte blastogenic response to mitogen and antigen by Leishmania tropica.

Sharma M, Anaraki F, Ala F Clin Exp Immunol. 1978; 32(3):477-83.

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