The Origin and Maintenance of Virulence for the Human Pathogenic Fungus Cryptococcus Neoformans

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2003 Jun 6

PMID 12787743

Citations 63

Authors

Judith N Steenbergen

Arturo Casadevall

Affiliations

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Abstract

The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators.

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