Genetic Vulnerability Following Traumatic Brain Injury: the Role of Apolipoprotein E

Overview

Journal Mol Pathol

Specialty Molecular Biology

Date 2003 Jun 5

PMID 12782758

Citations 34

Authors

N Nathoo

R Chetty

J R Van Dellen

G H Barnett

Affiliations

Soon will be listed here.

Abstract

Apolipoprotein E (APOE) is thought to be responsible for the transportation of lipids within the brain, maintaining structural integrity of the microtubule within the neurone, and assisting with neural transmission. Possession of the APOE epsilon4 allele has also been shown to influence neuropathological findings in patients who die from traumatic brain injury, including the accumulation of amyloid beta protein. Previous clinical studies reporting varying outcome severities of traumatic brain injury, including cognitive and functional recovery, all support the notion that APOE epsilon4 allele possession is associated with an unfavourable outcome. Evidence from experimental and clinical brain injury studies confirms that APOE plays an important role in the response of the brain to injury.

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References

Lynch J, Pineda J, Morgan D, Zhang L, Warner D, Benveniste H . Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol. 2002; 51(1):113-7. DOI: 10.1002/ana.10098. View

Uryu K, Laurer H, McIntosh T, Pratico D, Martinez D, Leight S . Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci. 2002; 22(2):446-54. PMC: 6758680. View

Liaquat I, Dunn L, Nicoll J, Teasdale G, Norrie J . Effect of apolipoprotein E genotype on hematoma volume after trauma. J Neurosurg. 2002; 96(1):90-6. DOI: 10.3171/jns.2002.96.1.0090. View

Graff-Radford N, Green R, Go R, Hutton M, Edeki T, Bachman D . Association between apolipoprotein E genotype and Alzheimer disease in African American subjects. Arch Neurol. 2002; 59(4):594-600. DOI: 10.1001/archneur.59.4.594. View

Crawford F, Vanderploeg R, Freeman M, Singh S, WAISMAN M, Michaels L . APOE genotype influences acquisition and recall following traumatic brain injury. Neurology. 2002; 58(7):1115-8. DOI: 10.1212/wnl.58.7.1115. View

Rozovsky I, Hoving S, Anderson C, OCallaghan J, Finch C . Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures. Neurosci Lett. 2002; 323(3):191-4. DOI: 10.1016/s0304-3940(02)00146-5. View

Roses A . Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med. 1996; 47:387-400. DOI: 10.1146/annurev.med.47.1.387. View

Greenberg S, Briggs M, Hyman B, Kokoris G, Takis C, Kanter D . Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke. 1996; 27(8):1333-7. DOI: 10.1161/01.str.27.8.1333. View

Zekraoui L, Lagarde J, Raisonnier A, Gerard N, Aouizerate A, Lucotte G . High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa. Hum Biol. 1997; 69(4):575-81. View

10.

Jordan B, Relkin N, Ravdin L, Jacobs A, Bennett A, Gandy S . Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA. 1997; 278(2):136-40. View

11.

Lichtman S, Seliger G, Tycko B, Marder K . Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation. Neurology. 2000; 55(10):1536-9. DOI: 10.1212/wnl.55.10.1536. View

12.

Sahota A, Yang M, Gao S, Hui S, Baiyewu O, Gureje O . Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent. Ann Neurol. 1997; 42(4):659-61. DOI: 10.1002/ana.410420418. View

13.

Kalaria R, Ogengo J, Patel N, Sayi J, Kitinya J, Chande H . Evaluation of risk factors for Alzheimer's disease in elderly east Africans. Brain Res Bull. 1997; 44(5):573-7. DOI: 10.1016/s0361-9230(97)00310-9. View

14.

Murai H, Pierce J, Raghupathi R, Smith D, Saatman K, Trojanowski J . Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. J Comp Neurol. 1998; 392(4):428-38. DOI: 10.1002/(sici)1096-9861(19980323)392:4<428::aid-cne2>3.0.co;2-2. View

15.

Hartman R, Laurer H, Longhi L, Bales K, Paul S, McIntosh T . Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci. 2002; 22(23):10083-7. PMC: 6758744. View

16.

Evans D, Bennett D, Wilson R, Bienias J, Morris M, Scherr P . Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. 2003; 60(2):185-9. DOI: 10.1001/archneur.60.2.185. View

17.

Nathoo N, Chetry R, van Dellen J, Connolly C, Naidoo R . Apolipoprotein E polymorphism and outcome after closed traumatic brain injury: influence of ethnic and regional differences. J Neurosurg. 2003; 98(2):302-6. DOI: 10.3171/jns.2003.98.2.0302. View

18.

Mahley R . Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988; 240(4852):622-30. DOI: 10.1126/science.3283935. View

19.

Sepehrnia B, Kamboh M, Adams-Campbell L, Nwankwo M, Ferrell R . Genetic studies of human apolipoproteins. VII. Population distribution of polymorphisms of apolipoproteins A-I, A-II, A-IV, C-II, E, and H in Nigeria. Am J Hum Genet. 1988; 43(6):847-53. PMC: 1715609. View

20.

Boyles J, Zoellner C, Anderson L, Kosik L, Pitas R, Weisgraber K . A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest. 1989; 83(3):1015-31. PMC: 303779. DOI: 10.1172/JCI113943. View