[Intestinal Disaccharidase and Alkaline Phosphatase Activities of Jejunal Biopsies in Small Bowel Diseases of Children (author's Transl)]

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1976 Mar 8

PMID 1278185

Authors

T Lucking

J Wenner

Affiliations

Soon will be listed here.

Abstract

Intestinal disaccharidase activities were determined in 294 jejunal biopsies obtained from 254 children with various disorders of the small bowel, and alkaline phosphatase activity was measured in 251 biopsies. In normal mucosa a broad range of enzyme activity was found corresponding with the data in the literature. A primary disaccharidase deficiency was observed in 5 children with congenital sucrase-isomaltase deficiency and in a 12-year-old Egyptian boy with acquired lactase deficiency. A secondary generalized depression of disaccharidase activity and a diminution of alkaline phosphatase activity existed chiefly in patients who had severe or moderate mucosal damage, also in active coeliac disease and during gluten loading, in protracted diarrhoea of infancy, chronic malabsorption of unknown origin and agammaglobulinemia. During remissions enzyme activities recovered together with mucosal improvement. Low levels of enzyme activities were also seen in some cases of protracted diarrhoea of infancy and chronic malabsorption of unknown origin although only mild mucosal lesions were demonstrated.

References

WEIJERS H, va de KAMER J, DICKE W, IJSSELING J . Diarrhoea caused by deficiency of sugar splitting enzymes. I. Acta Paediatr (Stockh). 1961; 50:55-71. DOI: 10.1111/j.1651-2227.1961.tb08022.x. View

Bolin T, Davis A . Primary lactase deficiency: genetic or acquired?. Gastroenterology. 1972; 62(2):355-7. View

Haemmerli U, KISTLER H, Ammann R, Auricchio S, PRADER A . [Lactate deficiency of the mucosa of the small intestine as the cause of certain forms of acquired milk intolerance in adults]. Helv Med Acta. 1963; 30(4):693-705. View

. Studies on infant diarrhea. IV. Sugar transit and absorp- tion in small intestine after a feeding. Gastroenterology. 1970; 59(3):396-403. View

PADYKULA H, STRAUSS E, LADMAN A, GARDNER F . A morphologic and histochemical analysis of the human jejunal epithelium in nontropical sprue. Gastroenterology. 1961; 40:735-65. View

Dahlqvist A, Lindberg T, Meeuwisse G, Akerman M . Intestinal dipeptidases and disaccharidases in children with malabsorption. Acta Paediatr Scand. 1970; 59(6):621-30. DOI: 10.1111/j.1651-2227.1970.tb17696.x. View

Gray G, Santiago N . Disaccharide absorption in normal and diseased human intestine. Gastroenterology. 1966; 51(4):489-98. View

Hamilton J, Lynch M, REILLY B . Active coeliac disease in childhood. Clinical and laboratory findings of forty-two cases. Q J Med. 1969; 38(150):135-58. View

Sheldon W, Tempany E . Small intestine peroral biopsy in coeliac children. Gut. 1966; 7(5):481-9. PMC: 1552507. DOI: 10.1136/gut.7.5.481. View

10.

CROSBY W, KUGLER H . Intraluminal biopsy of the small intestine; the intestinal biopsy capsule. Am J Dig Dis. 1957; 2(5):236-41. DOI: 10.1007/BF02231100. View

11.

Olatunbosun D, Adadevoh B . Lactose intolerance in Nigerian children. Acta Paediatr Scand. 1972; 61(6):715-9. DOI: 10.1111/j.1651-2227.1972.tb15973.x. View

12.

EGGSTEIN M, KREUTZ F . [Comparative studies of quantitative determination of proteins in cerebrospinal fluid and low-protein solutions]. Klin Wochenschr. 1955; 33(37-38):879-84. DOI: 10.1007/BF01473099. View

13.

Levin B, Abraham J, Burgess E, Wallis P . Congenital lactose malabsorption. Arch Dis Child. 1970; 45(240):173-7. PMC: 2020274. DOI: 10.1136/adc.45.240.173. View

14.

Lifshitz F . The response of infants to carbohydrate oral loads after recovery from diarrhea. J Pediatr. 1971; 79(4):612-7. DOI: 10.1016/s0022-3476(71)80308-6. View

15.

Gracey M, Burke V . Sugar-induced diarrhoea in children. Arch Dis Child. 1973; 48(5):331-6. PMC: 1648389. DOI: 10.1136/adc.48.5.331. View

16.

SHINER M . Jejunal-biopsy tube. Lancet. 1956; 270(6907):85. DOI: 10.1016/s0140-6736(56)92137-7. View

17.

Lifshitz F . Monosaccharide intolerance and hypoglycemia in infants with diarrhea. I. Clinical course of 23 infants. J Pediatr. 1970; 77(4):595-603. DOI: 10.1016/s0022-3476(70)80200-1. View

18.

Bolin T, Davis A, SEAH C, Chua K, Yong V, Kho K . Lactose intolerance in Singapore. Gastroenterology. 1970; 59(1):76-84. View

19.

Lifshitz F . Carbohydrate intolerance in infants with diarrhea. J Pediatr. 1971; 79(5):760-7. DOI: 10.1016/s0022-3476(71)80388-8. View

20.

Cuatrecasas P, Lockwood D, Caldwell J . LACTASE DEFICIENCY IN THE ADULT. A COMMON OCCURRENCE. Lancet. 1965; 1(7375):14-8. DOI: 10.1016/s0140-6736(65)90922-0. View