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Inhibition of Nitric Oxide Production on LPS-activated Macrophages by Kazinol B from Broussonetia Kazinoki

Overview
Journal Fitoterapia
Publisher Elsevier
Date 2003 Jun 5
PMID 12781805
Citations 15
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Abstract

The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 microg/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC(50) of 21.6 microM.

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