Repetitive Transcranial Magnetic Stimulation for the Treatment of Depression. Systematic Review and Meta-analysis

Overview

Journal Br J Psychiatry

Publisher Cambridge University Press

Specialty Psychiatry

Date 2003 Jun 5

PMID 12777338

Citations 57

Authors

Jose Luis R Martin

Manuel J Barbanoj

Thomas E Schlaepfer

Elinor Thompson

Victor Perez

Jaime Kulisevsky

Affiliations

Soon will be listed here.

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) may be useful in the treatment of depression but results from trials have been inconclusive to date.

Aims: To assess the efficacy of rTMS in treating depression.

Method: We conducted a systematic review of randomised controlled trials that compared rTMS with sham in patients with depression. We assessed the quality of design of all studies and conducted a meta-analysis of data from trials with similar rTMS delivery.

Results: We included a total of 14 trials. The quality of the included studies was low. Pooled analysis using the Hamilton Rating Scale for Depression showed an effect in favour of rTMS compared with sham after 2 weeks of treatment (standardised mean difference=-0.35; 95% CI -0.66 to -0.04), but this was not significant at the 2-week follow-up (standardised mean difference=-0.33; 95% CI -0.84 to 0.17).

Conclusions: Current trials are of low quality and provide insufficient evidence to support the use of rTMS in the treatment of depression.

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