The Kinetics of Immune Reconstitution After Cord Blood Transplantation and Selected CD34+ Stem Cell Transplantation in Children: Comparison with Bone Marrow Transplantation

Overview

Journal Int J Hematol

Specialty Hematology

Date 2003 May 31

PMID 12774932

Citations 9

Authors

Hiroyasu Inoue

Yukiharu Yasuda

Kinya Hattori

Takashi Shimizu

Masae Matsumoto

Miharu Yabe

Hiromasa Yabe

Fumiko Tsuchida

Yumiko Tanaka

Gaku Hosoi

Masahiro Sako

Shunichi Kato

Affiliations

Soon will be listed here.

Abstract

The present study compares immune reconstitution after allogeneic cord blood transplantation (CBT) and CD34+ stem cell transplantation (CD34-SCT) with that after bone marrow transplantation (BMT). Eighty-eight children who underwent CBT (20 patients), BMT (58), and CD34-SCT (10) were enrolled, and lymphocytes and T-, B-, and natural killer-lymphocyte subsets were monitored for more than 5 years after transplantation. CBT recipients showed significant ircreases in (1) total lymphocyte counts (P < .001), (2) CD4+/CD8+ cell ratios (P < .01), (3) CD4+ and CD4+CD45RA+ cells (P < .001), (4) CD8+CD11b+ cells (P < .001), and (5) CD19+ and CD19+CD5+ cells (P < .0001) and marked decreases in the frequencies of CD8+ and CD8+CD11b- cells (P < .0001). CD34-SCT recipients showed lower lymphocyte counts in the first 6 months and an emergence of lymphocyte and CD4+CD45RA+ cells at approximately 9 months and 1 year. Both CBT and CD34-SCT recipients showed increased frequencies of CD56+ cells at 1 month (CD34-SCT versus BMT, P < .001) but decreased frequencies after 6 months (CBT versus BMT, P < .001). Lymphoproliferative responses to exogenous interleukin 2 were constantly lower in CBT and CD34-SCT recipients than in BMT recipients. These results suggest that the delay in immune reconstitution after CBT in the early phase was mainly qualitative and related to the immaturity of cells, whereas the delay in CD34-SCT was mainly quantitative in the first several months.

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