Dental Treatment Prior to Stem Cell Transplantation and Its Influence on the Posttransplantation Outcome

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2003 May 28

PMID 12768464

Citations 24

Authors

A B Melkos

G Massenkeil

R Arnold

P A Reichart

Affiliations

Soon will be listed here.

Abstract

Patients who receive allogeneic stem cell transplantation (SCT) for hematological malignancies are at increased risk of developing oral complications. To reduce morbidity pretransplantation dental evaluation and treatment of all sources of potential infection have become standard of care for these patients. This study examined the effect of dental foci on the posttransplantation (post-SCT) outcome in two groups of patients who underwent allogeneic or autologous SCT: those who had no dental foci or completed dental treatment preoperatively (n=36) and those who underwent SCT without dental interventions (n=22). Statistical analysis showed no significant correlations between dental foci and infections, mucositis, and survival rate post-SCT. We therefore do not recommend a radical dental treatment pre-SCT.

Citing Articles

Oral foci of infection and their relationship with hospital stay after haematopoietic cell transplantation.

van Gennip L, Thomas R, Bulthuis M, Hannink G, Bronkhorst E, Blijlevens N Support Care Cancer. 2024; 32(12):816.

PMID: 39578296 PMC: 11584470. DOI: 10.1007/s00520-024-08991-5.

Retrospective analysis of the effects of impacted third molar on hematologic patients undergoing hematopoietic stem cell transplantation.

Zhao S, Gao X, Wang S, Sun Y, Gao C Heliyon. 2024; 10(11):e32502.

PMID: 38961967 PMC: 11219483. DOI: 10.1016/j.heliyon.2024.e32502.

Influence of periodontal status on patients undergoing hematopoietic stem cell transplantation: A retrospective analysis.

Gao X, Zhao S, Wang S, Sun Y, Gao C Heliyon. 2024; 10(10):e30998.

PMID: 38778978 PMC: 11108988. DOI: 10.1016/j.heliyon.2024.e30998.

Pre-Chemotherapy Dental Screening: Is There Additional Diagnostic Value for a Panoramic Radiograph?.

Zecha J, Laheij A, Raber-Durlacher J, Westermann A, de Lange J, Smeele L Dent J (Basel). 2023; 11(5).

PMID: 37232773 PMC: 10217215. DOI: 10.3390/dj11050122.

Dental Evaluation Prior to Cancer Therapy.

Yong C, Robinson A, Hong C Front Oral Health. 2022; 3:876941.

PMID: 35510226 PMC: 9058061. DOI: 10.3389/froh.2022.876941.

References

Einsele H, Kanz L . [Allogeneic transplantation of stem cells]. Internist (Berl). 2000; 40(12):1249-56. DOI: 10.1007/s001080050463. View

Peters E, Monopoli M, Woo S, Sonis S . Assessment of the need for treatment of postendodontic asymptomatic periapical radiolucencies in bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol. 1993; 76(1):45-8. DOI: 10.1016/0030-4220(93)90292-c. View

Heimdahl A, Mattsson T, Dahllof G, Lonnquist B, Ringden O . The oral cavity as a port of entry for early infections in patients treated with bone marrow transplantation. Oral Surg Oral Med Oral Pathol. 1989; 68(6):711-6. DOI: 10.1016/0030-4220(89)90160-6. View

Lazarchik D, Filler S, Winkler M . Dental evaluation in bone marrow transplantation. Gen Dent. 1995; 43(4):369-71. View

Bergmann O . Oral infections and septicemia in immunocompromised patients with hematologic malignancies. J Clin Microbiol. 1988; 26(10):2105-9. PMC: 266825. DOI: 10.1128/jcm.26.10.2105-2109.1988. View

Margolis J, Borrello I, Flinn I . New approaches to treating malignances with stem cell transplantation. Semin Oncol. 2000; 27(5):524-30. View

Storb R, Buckner C . Human bone marrow transplantation. Eur J Clin Invest. 1990; 20(2):119-32. DOI: 10.1111/j.1365-2362.1990.tb02258.x. View

Secola R . Hematopoietic stem cell transplantation: a glimpse of the past and a view of the future. J Pediatr Oncol Nurs. 2001; 18(4):171-7. DOI: 10.1053/jpon.2001.24799. View

Akintoye S, Brennan M, Graber C, McKinney B, Rams T, Barrett A . A retrospective investigation of advanced periodontal disease as a risk factor for septicemia in hematopoietic stem cell and bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94(5):581-8. DOI: 10.1067/moe.2002.128960. View

10.

Boraz R, Myers R . A national survey of dental protocols for the patient with a cardiac transplant. Spec Care Dentist. 1990; 10(1):26-9. DOI: 10.1111/j.1754-4505.1990.tb01083.x. View

11.

Meyer U, Weingart D, Deng M, Scheld H, Joos U . Heart transplants--assessment of dental procedures. Clin Oral Investig. 2000; 3(2):79-83. DOI: 10.1007/s007840050082. View

12.

Nash R, Pepe M, Storb R, Longton G, Pettinger M, Anasetti C . Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood. 1992; 80(7):1838-45. View

13.

Sonis S, Kunz A . Impact of improved dental services on the frequency of oral complications of cancer therapy for patients with non-head-and-neck malignancies. Oral Surg Oral Med Oral Pathol. 1988; 65(1):19-22. DOI: 10.1016/0030-4220(88)90184-3. View

14.

Wilson R, Whelchel J, Lordon R . Occult dental infection causing fever in renal transplant patients. Am J Kidney Dis. 1982; 2(3):354-6. DOI: 10.1016/s0272-6386(82)80094-2. View