The Selenium and Vitamin E Cancer Prevention Trial

Overview

Journal World J Urol

Specialty Urology

Date 2003 May 21

PMID 12756490

Citations 15

Authors

Eric A Klein

Scott M Lippman

Ian M Thompson

Phyllis J Goodman

Demetrius Albanes

Philip R Taylor

Charles Coltman

Affiliations

Soon will be listed here.

Abstract

Background: Evidence suggests that both selenium and vitamin E reduce the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized, prospective, double-blind study designed to determine whether selenium and vitamin E alone and in combination can reduce the risk of prostate cancer among healthy men.

Materials And Methods: The preclinical and epidemiological evidence supporting a role for selenium and vitamin E as chemopreventive agents in prostate cancer are reviewed, and details of the trial design are presented. RESULTS. Preclinical, epidemiological, and phase III data from randomized, placebo-controlled clinical trials suggest that both selenium and vitamin E have potential efficacy in prostate cancer prevention. SELECT is a 2x2 factorial study with an accrual goal of 32,400 men with nonsuspicious DRE and serum PSA of 4 ng/ml or lower.

Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment began in 2001 with final results anticipated in 2013.

Citing Articles

Selenium for preventing cancer.

Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M Cochrane Database Syst Rev. 2018; 1:CD005195.

PMID: 29376219 PMC: 6491296. DOI: 10.1002/14651858.CD005195.pub4.

Selenium for preventing cancer.

Vinceti M, Dennert G, Crespi C, Zwahlen M, Brinkman M, Zeegers M Cochrane Database Syst Rev. 2014; (3):CD005195.

PMID: 24683040 PMC: 4441528. DOI: 10.1002/14651858.CD005195.pub3.

Quality of education and memory test performance in older men: the New York University Paragraph Recall Test normative data.

Mathews M, Abner E, Caban-Holt A, Dennis B, Kryscio R, Schmitt F Curr Alzheimer Res. 2013; 10(7):776-83.

PMID: 23906000 PMC: 4030724. DOI: 10.2174/15672050113109990140.

CERAD practice effects and attrition bias in a dementia prevention trial.

Mathews M, Abner E, Caban-Holt A, Kryscio R, Schmitt F Int Psychogeriatr. 2013; 25(7):1115-23.

PMID: 23570673 PMC: 4012228. DOI: 10.1017/S1041610213000367.

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.

Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C Cochrane Database Syst Rev. 2012; (3):CD007176.

PMID: 22419320 PMC: 8407395. DOI: 10.1002/14651858.CD007176.pub2.

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