(Patho)physiological Implications of the Novel Epithelial Ca2+ Channels TRPV5 and TRPV6

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2003 May 16

PMID 12748856

Citations 26

Authors

Tom Nijenhuis

Joost G J Hoenderop

Bernd Nilius

Rene J M Bindels

Affiliations

Soon will be listed here.

Abstract

The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca(2+) channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca(2+) channels.

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