Extensive Cortical Damage in a Case of Creutzfeldt-Jacob Disease: Clinicoradiological Correlations

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 2003 May 14

PMID 12743664

Citations 5

Authors

M Bergui

G B Bradac

G Rossi

L Orsi

Affiliations

Soon will be listed here.

Abstract

MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jacob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.

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