Changing Neighbours, Changing Behaviour: Cell Adhesion Molecule-mediated Signalling During Tumour Progression

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2003 May 14

PMID 12743026

Citations 86

Authors

Gerhard Christofori

Affiliations

Soon will be listed here.

Abstract

Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.

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