Association of Polymorphisms of the Tumour Necrosis Factor Receptors I and II and Rheumatoid Arthritis

Overview

Journal Rheumatology (Oxford)

Publisher Oxford University Press

Specialty Rheumatology

Date 2003 May 6

PMID 12730509

Citations 3

Authors

J-P Bayley

A M Bakker

E L Kaijzel

T W J Huizinga

C L Verweij

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients.

Methods: A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for the TNF-RI exon 1 (+36 A to G) and TNF-RII 3' UTR (+1690 T to C) polymorphisms.

Results: The frequencies of the TNF-RI and TNF-RII polymorphisms were determined in both patient groups and healthy controls, but no significant differences were found. To determine the relationship of these polymorphisms to disease severity, the extent of joint damage in the cohort of 90 female RA patients was analysed. No differences in severity were observed.

Conclusion: These TNF-RI and TNF-RII polymorphisms were not found to be associated with susceptibility to or severity of RA in the Dutch population.

Citing Articles

TNF-α gene polymorphisms and expression.

El-Tahan R, Ghoneim A, El-Mashad N Springerplus. 2016; 5(1):1508.

PMID: 27652081 PMC: 5014780. DOI: 10.1186/s40064-016-3197-y.

Associations between functional TNFR2 196 M/R polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.

Song G, Bae S, Lee Y Rheumatol Int. 2014; 34(11):1529-37.

PMID: 24777778 DOI: 10.1007/s00296-014-3027-x.

Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFalpha therapy in rheumatoid arthritis?.

Ongaro A, De Mattei M, Pellati A, Caruso A, Ferretti S, Masieri F Rheumatol Int. 2008; 28(9):901-8.

PMID: 18309487 DOI: 10.1007/s00296-008-0552-5.