Gnetol As a Potent Tyrosinase Inhibitor from Genus Gnetum

Overview

Journal Biosci Biotechnol Biochem

Publisher Oxford University Press

Specialties Biochemistry
Biotechnology

Date 2003 May 2

PMID 12723623

Citations 13

Authors

Kenji Ohguchi

Toshiyuki Tanaka

Ibrahim Iliya

Tetsuro Ito

Munekazu Iinuma

Kenji Matsumoto

Yukihiro Akao

Yoshinori Nozawa

Affiliations

Soon will be listed here.

Abstract

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.

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