EBNA2 and Activated Notch Induce Expression of BATF

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2003 Apr 30

PMID 12719594

Citations 26

Authors

Lisa M Johansen

Christopher D Deppmann

Kimberly D Erickson

William F Coffin 3rd

Tina M Thornton

Sean E Humphrey

Jennifer M Martin

Elizabeth J Taparowsky

Affiliations

Soon will be listed here.

Abstract

The immortalization of human B lymphocytes by Epstein-Barr virus (EBV) requires the virus-encoded transactivator EBNA2 and the products of both viral and cellular genes which serve as EBNA2 targets. In this study, we identified BATF as a cellular gene that is up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV. The transactivation of BATF is mediated by EBNA2 in a B-cell-specific manner and is duplicated in non-EBV-infected B cells by the expression of mammalian Notch proteins. In contrast to other target genes activated by EBNA2, the BATF gene encodes a member of the AP-1 family of transcription factors that functions as a negative regulator of AP-1 activity and as an antagonist of cell growth. A potential role for BATF in promoting EBV latency is supported by studies in which BATF was shown to negatively impact the expression of a BZLF1 reporter gene and to reduce the frequency of lytic replication in latently infected cells. The identification of BATF as a cellular target of EBV provides important new information on how programs of viral and cellular gene expression may be coordinated to promote viral latency and control lytic-cycle entry.

Citing Articles

The role of BATF in immune cell differentiation and autoimmune diseases.

Wang X, Hong Y, Zou J, Zhu B, Jiang C, Lu L Biomark Res. 2025; 13(1):22.

PMID: 39876010 PMC: 11776340. DOI: 10.1186/s40364-025-00733-x.

A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism.

Lamontagne R, Soldan S, Su C, Wiedmer A, Won K, Lu F PLoS Pathog. 2021; 17(1):e1009208.

PMID: 33497421 PMC: 7864721. DOI: 10.1371/journal.ppat.1009208.

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells.

Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T mSphere. 2018; 3(6).

PMID: 30487153 PMC: 6262262. DOI: 10.1128/mSphere.00478-18.

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications.

Giunco S, Petrara M, Zangrossi M, Celeghin A, de Rossi A Infect Agent Cancer. 2018; 13:14.

PMID: 29643934 PMC: 5892012. DOI: 10.1186/s13027-018-0186-5.

Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B.

Wang L, Fan Y, Zhao J, Ji X, Wang K Clin Exp Med. 2017; 18(2):263-272.

PMID: 29164410 DOI: 10.1007/s10238-017-0480-3.

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