JC Virus Agnoprotein Colocalizes with Tubulin

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2003 Apr 24

PMID 12709865

Citations 8

Authors

Shuichi Endo

Yuki Okada

Yasuko Orba

Hiroshi Nishihara

Shinya Tanaka

Kazuo Nagashima

Hirofumi Sawa

Affiliations

Soon will be listed here.

Abstract

The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

Citing Articles

The oncogenic roles of JC polyomavirus in cancer.

Zheng H, Xue H, Zhang C Front Oncol. 2022; 12:976577.

PMID: 36212474 PMC: 9537617. DOI: 10.3389/fonc.2022.976577.

Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40.

Saribas A, Coric P, Bouaziz S, Safak M J Cell Physiol. 2018; 234(6):8295-8315.

PMID: 30390301 PMC: 6395527. DOI: 10.1002/jcp.27715.

Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins.

To J, Torres J Subcell Biochem. 2018; 88:329-377.

PMID: 29900504 PMC: 7122450. DOI: 10.1007/978-981-10-8456-0_15.

Agnoprotein of mammalian polyomaviruses.

Gerits N, Moens U Virology. 2012; 432(2):316-26.

PMID: 22726243 PMC: 7111918. DOI: 10.1016/j.virol.2012.05.024.

Potential mechanisms of the human polyomavirus JC in neural oncogenesis.

Del Valle L, White M, Khalili K J Neuropathol Exp Neurol. 2008; 67(8):729-40.

PMID: 18648329 PMC: 2771681. DOI: 10.1097/NEN.0b013e318180e631.

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