Human T-cell Lymphotropic Virus Type I and Neurological Diseases

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2003 Apr 23

PMID 12707853

Citations 26

Authors

Masahiro Nagai

Mitsuhiro Osame

Affiliations

Soon will be listed here.

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) infection is associated with a variety of human diseases. In particular, there are two major diseases caused by HTLV-I infection. One is an aggressive neoplastic disease called adult T-cell leukemia (ATL), and another is a chronic progressive inflammatory neurological disease called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is still unknown why one virus causes these different diseases. With regard to HAM/TSP, virus-host immunological interactions are an considered to be important cause of this disease. Coexisting high HTLV-I proviral load and HTLV-I-specific T cells (CD4+ T cells and CD8+ T cells) is an important feature of HAM/TSP. Histopathological studies indicate the existence of an inflammatory reaction and HTLV-I-infected cells in the affected lesions of HAM/TSP. Therefore, the immune response to HTLV-I probably contributes to the inflammatory process of the central nervous system lesions in HAM/TSP patients.

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References

Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Moritoyo T . Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol. 1999; 4(6):586-93. DOI: 10.3109/13550289809114225. View

Koenig S, Woods R, Brewah Y, Newell A, Jones G, Boone E . Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease. J Immunol. 1993; 151(7):3874-83. View

Biddison W, Kubota R, Kawanishi T, Taub D, Cruikshank W, Center D . Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J Immunol. 1997; 159(4):2018-25. View

Jeffery K, Usuku K, Hall S, Matsumoto W, Taylor G, Procter J . HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A. 1999; 96(7):3848-53. PMC: 22383. DOI: 10.1073/pnas.96.7.3848. View

Hara H, Morita M, Iwaki T, Hatae T, Itoyama Y, Kitamoto T . Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor V beta CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Exp Med. 1994; 180(3):831-9. PMC: 2191665. DOI: 10.1084/jem.180.3.831. View

Kaplan J, Osame M, Kubota H, Igata A, Nishitani H, Maeda Y . The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J Acquir Immune Defic Syndr (1988). 1990; 3(11):1096-101. View

Lehky T, Fox C, Koenig S, Levin M, Flerlage N, Izumo S . Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. Ann Neurol. 1995; 37(2):167-75. DOI: 10.1002/ana.410370206. View

Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y . HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes. AIDS Res Hum Retroviruses. 2001; 17(11):1047-61. DOI: 10.1089/088922201300343735. View

Hausmann S, Biddison W, Smith K, Ding Y, Garboczi D, Utz U . Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. J Immunol. 1999; 162(9):5389-97. View

10.

Jacobson S, Shida H, McFarlin D, Fauci A, Koenig S . Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature. 1990; 348(6298):245-8. DOI: 10.1038/348245a0. View

11.

Szymocha R, Akaoka H, Dutuit M, Malcus C, Belin M, Giraudon P . Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol. 2000; 74(14):6433-41. PMC: 112151. DOI: 10.1128/jvi.74.14.6433-6441.2000. View

12.

Bieganowska K, Hollsberg P, Buckle G, Lim D, Greten T, Schneck J . Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J Immunol. 1999; 162(3):1765-71. View

13.

Nagai M, Brennan M, Sakai J, Mora C, Jacobson S . CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood. 2001; 98(6):1858-61. DOI: 10.1182/blood.v98.6.1858. View

14.

Nagai M, Yashiki S, Fujiyoshi T, Fujiyama C, Kitze B, Izumo S . Characterization of a unique T-cell clone established from a patient with HAM/TSP which recognized HTLV-I-infected T-cell antigens as well as spinal cord tissue antigens. J Neuroimmunol. 1996; 65(2):97-105. DOI: 10.1016/0165-5728(96)00002-1. View

15.

Umehara F, Izumo S, Takeya M, Takahashi K, Sato E, Osame M . Expression of adhesion molecules and monocyte chemoattractant protein -1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy. Acta Neuropathol. 1996; 91(4):343-50. DOI: 10.1007/s004010050435. View

16.

Parker C, Nightingale S, Taylor G, Weber J, Bangham C . Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol. 1994; 68(5):2860-8. PMC: 236774. DOI: 10.1128/JVI.68.5.2860-2868.1994. View

17.

Hanon E, Stinchcombe J, Saito M, Asquith B, Taylor G, Tanaka Y . Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity. 2000; 13(5):657-64. DOI: 10.1016/s1074-7613(00)00065-0. View

18.

Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M . HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol. 1988; 23 Suppl:S143-50. DOI: 10.1002/ana.410230733. View

19.

Jeffery K, Siddiqui A, Bunce M, Lloyd A, Vine A, Witkover A . The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol. 2000; 165(12):7278-84. DOI: 10.4049/jimmunol.165.12.7278. View

20.

Umehara F, Okada Y, Fujimoto N, Abe M, Izumo S, Osame M . Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol. 1998; 57(9):839-49. DOI: 10.1097/00005072-199809000-00005. View