Mechanisms of Pain in Chronic Pelvic Pain Syndrome: Influence of Prostatic Inflammation

Overview

Journal World J Urol

Specialty Urology

Date 2003 Apr 18

PMID 12700922

Citations 5

Authors

Aare Mehik

Markku J Leskinen

Pekka Hellstrom

Affiliations

Soon will be listed here.

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), is of considerable interest in clinical urology. During the past decade, several new approaches have been made to discover its aetiology and pathophysiological mechanisms and to develop treatment modalities. The aetiology of CPPS has remained unresolved. Bacterial, chemical, urodynamic and immunological aetiologies have been suggested, but none of these has been conclusively proven. The histopathological changes in CP and CPPS are relatively well known, but the pathophysiological changes that lead to chronic inflammation and prolonged symptoms are still poorly understood. This review proposes an additional approach to the pathophysiology of CPPS. The concept of prostate tissue pressure is introduced as an objectively measurable parameter in evaluating the inflammatory process in CPPS. Chronic pain due to neurogenic inflammation and altered mast cell function is also discussed.

Citing Articles

Research progress on the relationship between chronic prostatitis/chronic pelvic pain syndrome and the microbiota of the reproductive system.

Song W, Liu X, He L Front Cell Infect Microbiol. 2024; 14:1417276.

PMID: 38975329 PMC: 11224459. DOI: 10.3389/fcimb.2024.1417276.

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy.

Tsai M, Kao L, Lin H, Lee C, Chung S Can Urol Assoc J. 2018; 11(9):E367-E371.

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The Vascular Factor Plays the Main Role in the Cause of Pain in Men with Chronic Prostatitis and Chronic Pelvic Pain Syndrome: The Results of Clinical Trial on Thermobalancing Therapy.

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Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation.

Fuentes I, Pierce A, ONeil P, Christianson J J Vis Exp. 2015; (102):e53181.

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[Chronic pain in urology: inguinal pain, post vasectomy pain, and chronic pelvic pain].

Ozgur E, Dagtekin O Wien Med Wochenschr. 2009; 159(21-22):543-7.

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