Prostaglandin Release in Canine Acute Haemorrhagic Pancreatitis

Overview

Journal Gut

Specialty Gastroenterology

Date 1976 Jan 1

PMID 1269976

Citations 7

Authors

G Glazer

A Bennett

Affiliations

Soon will be listed here.

Abstract

Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. Chromatographic analysis of the peritoneal exudate from the dogs with pancreatitis showed high levels of prostaglandin E-like material (mean 43 ng/ml prostaglandin E2 equivalents). It seems likely that prostaglandins contribute to the induced pancreatitis.

Citing Articles

Hemodynamic and metabolic impairment in acute pancreatitis.

Di Carlo V, Nespoli A, Chiesa R, Staudacher C, Cristallo M, Bevilacqua G World J Surg. 1981; 5(3):329-39.

PMID: 7293195 DOI: 10.1007/BF01657989.

Results of surgical treatment of necrotizing pancreatitis.

Beger H, Krautzberger W, Bittner R, Block S, Buchler World J Surg. 1985; 9(6):972-9.

PMID: 4082619 DOI: 10.1007/BF01655406.

Continuous peritoneal dialysis in acute experimental pancreatitis in dogs. Effect of aprotinin in the dialysate medium.

Bassi C, Briani G, Vesentini S, Orcalli F, Falconi M, Vantini I Int J Pancreatol. 1989; 5(1):69-75.

PMID: 2473149 DOI: 10.1007/BF02925699.

Renal function in experimentally induced acute pancreatitis in dogs: how it is affected by the nephrotoxic substance in pancreatic exudate from ascitic fluid.

Satake K, Kanazawa G, Hiura A, Nishiwaki H, Ha S, Chung Y Jpn J Surg. 1991; 21(1):88-95.

PMID: 2041247 DOI: 10.1007/BF02470871.

Therapeutic effect of isovolemic hemodilution with dextran 60 on the impairment of pancreatic microcirculation in acute biliary pancreatitis.

Klar E, Herfarth C, Messmer K Ann Surg. 1990; 211(3):346-53.

PMID: 1689993 PMC: 1358441. DOI: 10.1097/00000658-199003000-00006.

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