Protective Mechanisms Against the Antitumor Agent Bleomycin: Lessons from Saccharomyces Cerevisiae

Overview

Journal Curr Genet

Specialty Genetics

Date 2003 Apr 17

PMID 12698269

Citations 18

Authors

Dindial Ramotar

Huijie Wang

Affiliations

Soon will be listed here.

Abstract

Bleomycin is a small glycopeptide antibiotic used in combination therapy for the treatment of a few types of human cancer. The antitumor effect of bleomycin is most likely caused by its ability to bind to DNA and induce the formation of toxic DNA lesions via a free radical reactive (Fe.bleomycin) complex. However, the chemotherapeutic potential of bleomycin is limited, as it causes pulmonary fibrosis and tumor resistance at high doses. The chemical structure and modes of action of bleomycin have been extensively studied and these provide a foundation towards improving the therapeutic value of the drug. This review provides a first account of the current state of knowledge of the cellular processes that can allow the yeast Saccharomyces cerevisiae to evade the lethal effects of bleomycin. This model organism is likely to provide rapid clues in our understanding of bleomycin resistance in tumor cells.

Citing Articles

Uncovering Bleomycin-Induced Genomic Alterations and Underlying Mechanisms in the Yeast .

Zheng D, Wang Y, Zhu Y, Sheng H, Li K, Sui Y Appl Environ Microbiol. 2021; 88(2):e0170321.

PMID: 34731050 PMC: 8788679. DOI: 10.1128/AEM.01703-21.

Breast Cancer-Derived Microvesicles Are the Source of Functional Metabolic Enzymes as Potential Targets for Cancer Therapy.

Risha Y, Susevski V, Huttmann N, Poolsup S, Minic Z, Berezovski M Biomedicines. 2021; 9(2).

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Yeast Lacking the PP2A Phosphatase Regulatory Subunit Rts1 Sensitizes Mutants to Specific DNA Damaging Agents.

Aouida M, Eshrif A, Ramotar D Front Genet. 2019; 10:1117.

PMID: 31781172 PMC: 6857479. DOI: 10.3389/fgene.2019.01117.

Rapid functional activation of a horizontally transferred eukaryotic gene in a bacterial genome in the absence of selection.

Li Z, Bock R Nucleic Acids Res. 2019; 47(12):6351-6359.

PMID: 31106341 PMC: 6614815. DOI: 10.1093/nar/gkz370.

Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway.

He Y, Lan Y, Liu Y, Yu H, Han Z, Li X Molecules. 2016; 21(7).

PMID: 27376254 PMC: 6274306. DOI: 10.3390/molecules21070862.

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