Noncovalent Functionalization of Carbon Nanotubes for Highly Specific Electronic Biosensors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2003 Apr 17

PMID 12697899

Citations 172

Authors

Robert J Chen

Sarunya Bangsaruntip

Katerina A Drouvalakis

Nadine Wong Shi Kam

Moonsub Shim

Yiming Li

Woong Kim

Paul J Utz

Hongjie Dai

Affiliations

Soon will be listed here.

Abstract

Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

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