Aminophosphonic Acids of Potential Medical Importance

Overview

Journal Curr Med Chem Anticancer Agents

Publisher Bentham Science Publishers

Specialties Chemistry
Oncology

Date 2003 Apr 8

PMID 12678760

Citations 53

Authors

P Kafarski

B Lejczak

Affiliations

Soon will be listed here.

Abstract

Aminophosphonic acids were almost unknown in 1959 but today they are the subject of more than 6000 papers. Their negligible mammalian toxicity, and the fact that they very efficiently mimic aminocarboxylic acids makes them extremely important antimetabolites, which compete with their carboxylic counterparts for the active sites of enzymes and other cell receptors. Although biological importance of these compounds was recognized over 50 years ago they still represent promising and somewhat undiscovered class of potential drugs.

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