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Proposal for a Unified CCN Nomenclature

Overview
Journal Mol Pathol
Specialty Molecular Biology
Date 2003 Apr 1
PMID 12665631
Citations 107
Authors
D R Brigstock
R Goldschmeding
K-I Katsube
S C-T Lam
L F Lau
K Lyons
C Naus
B Perbal
B Riser
M Takigawa
H Yeger
Affiliations
Soon will be listed here.
Abstract

A proposal is put forth to unify the nomenclature of the CCN family of secreted, cysteine rich regulatory proteins. In the order of their description in the literature, CCN1 (CYR61), CCN2 (CTGF), CCN3 (NOV), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3) constitute a family of matricellular proteins that regulate cell adhesion, migration, proliferation, survival, and differentiation, at least in part through integrin mediated mechanisms. This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules.

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