Role of Mobile DNA in the Evolution of Vancomycin-resistant Enterococcus Faecalis

Overview

Journal Science

Specialty Science

Date 2003 Mar 29

PMID 12663927

Citations 470

Authors

I T Paulsen

L Banerjei

G S A Myers

K E Nelson

R Seshadri

T D Read

D E Fouts

J A Eisen

S R Gill

J F Heidelberg

H Tettelin

R J Dodson

L Umayam

L Brinkac

M Beanan

S Daugherty

R T Deboy

S Durkin

J Kolonay

R Madupu

W Nelson

J Vamathevan

B Tran

J Upton

T Hansen

J Shetty

H Khouri

T Utterback

D Radune

K A Ketchum

B A Dougherty

C M Fraser

Affiliations

Soon will be listed here.

Abstract

The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.

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