Quantitative Evaluation of DNA Fragmentation

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2003 Mar 28

PMID 12660836

Citations 9

Authors

T S Kalinina

A V Bannova

N N Dygalo

Affiliations

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Abstract

A new method for evaluation of DNA fragmentation in tissue is based on computer-aided densitometric standardization of the sum of optical densities of DNA fragments visualized by electrophoresis (180-2500 b. p.) in comparison with the density of high molecular weight DNA in the same sample. The method allows evaluation of DNA fragmentation, an acknowledged marker of apoptosis, in the fetal rat brain and detection of increased DNA fragmentation during stress and under the effect of glucocorticoids.

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