» Articles » PMID: 12654022

Hyperactivated Motility in Sperm

Overview
Date 2003 Mar 26
PMID 12654022
Citations 43
Authors
Affiliations
Soon will be listed here.
Abstract

Hyperactivation is a movement pattern seen in sperm at the site and time of fertilization in mammals. It may be critical to the success of fertilization, because it enhances the ability of sperm to detach from the wall of the oviduct, to move around in the labyrinthine lumen of the oviduct, to penetrate mucous substances and, finally, to penetrate the zona pellucida of the oocyte. The movement of hyperactivated sperm appears different under different physical conditions and in different species, but basically it involves an increase in flagellar bend amplitude and, usually, beat asymmetry. Presumably, a signal or signals exist in the oviduct to initiate hyperactivation at the appropriate time; however, none has yet been identified with certainty. While the signal transduction cascade regulating hyperactivation remains to be completely described, it is clear that calcium ions interact with the axoneme of the flagellum to switch on hyperactivation. Although hyperactivation often occurs during the process of capacitation, the two events are regulated by somewhat different pathways.

Citing Articles

Boar Sperm Motility Assessment Using Computer-Assisted Sperm Analysis: Current Practices, Limitations, and Methodological Challenges.

Hackerova L, Pilsova A, Pilsova Z, Zelenkova N, Tymich Hegrova P, Klusackova B Animals (Basel). 2025; 15(3).

PMID: 39943075 PMC: 11816302. DOI: 10.3390/ani15030305.


Addition of seminal plasma proteins effecting the  kinetic properties of canine spermatozoa.

Tsvetkov T, Petrova N, Daskalova D Vet Med (Praha). 2024; 67(7):365-370.

PMID: 39100133 PMC: 11295875. DOI: 10.17221/73/2021-VETMED.


Label-free, high-throughput holographic imaging to evaluate mammalian gametes and embryos†.

Wheeler M, Rabel R, Rubessa M, Popescu G Biol Reprod. 2024; 110(6):1125-1134.

PMID: 38733568 PMC: 11180620. DOI: 10.1093/biolre/ioae057.


Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015-2021 in a fertility center from China.

Li Y, Lu T, Wu Z, Wang Z, Yu T, Wang H Front Endocrinol (Lausanne). 2023; 14:1194455.

PMID: 37529601 PMC: 10390301. DOI: 10.3389/fendo.2023.1194455.


QTLs and Candidate Genes Associated with Semen Traits in Merino Sheep.

Hodge M, de Las Heras-Saldana S, Rindfleish S, Stephen C, Pant S Animals (Basel). 2023; 13(14).

PMID: 37508063 PMC: 10376747. DOI: 10.3390/ani13142286.