The Promise of Gene Therapy in Gastrointestinal and Liver Diseases

Overview

Journal Gut

Specialty Gastroenterology

Date 2003 Mar 26

PMID 12651882

Citations 13

Authors

J Prieto

M Herraiz

B Sangro

C Qian

G Mazzolini

I Melero

J Ruiz

Affiliations

Soon will be listed here.

Abstract

Gene therapy consists of the transfer of genetic material to cells to achieve a therapeutic goal. In the field of gastroenterology and hepatology gene therapy has produced considerable expectation as a potential tool in the management of conditions that lack effective therapy including non-resectable neoplasms of the liver, pancreas and gastrointestinal tract, chronic viral hepatitis unresponsive to interferon therapy, liver cirrhosis, and inflammatory bowel disease.

Citing Articles

Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives.

Yue N, Xu H, Xu J, Zhu M, Zhang Y, Tian C Mol Ther Oncolytics. 2023; 30:193-215.

PMID: 37663132 PMC: 10471515. DOI: 10.1016/j.omto.2023.08.007.

miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally?.

Hossian A, Mackenzie G, Mattheolabakis G Nanomedicine (Lond). 2019; 14(21):2873-2889.

PMID: 31735124 PMC: 7026766. DOI: 10.2217/nnm-2019-0180.

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS.

Crystal R, Pagovich O Trans Am Clin Climatol Assoc. 2018; 129:250-265.

PMID: 30166721 PMC: 6116601.

Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis.

Matsumoto H, Haga K, Ohno I, Hiraoka K, Kimura T, Hermann K BMC Gastroenterol. 2014; 14:68.

PMID: 24712338 PMC: 3991919. DOI: 10.1186/1471-230X-14-68.

Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors.

Matsumoto H, Kimura T, Haga K, Kasahara N, Anton P, McGowan I BMC Gastroenterol. 2010; 10:44.

PMID: 20459837 PMC: 2881878. DOI: 10.1186/1471-230X-10-44.

References

Zhang W . Development and application of adenoviral vectors for gene therapy of cancer. Cancer Gene Ther. 1999; 6(2):113-38. DOI: 10.1038/sj.cgt.7700024. View

Gambhir S, Barrio J, Phelps M, Iyer M, Namavari M, Satyamurthy N . Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A. 1999; 96(5):2333-8. PMC: 26784. DOI: 10.1073/pnas.96.5.2333. View

Kalpana G . Retroviral vectors for liver-directed gene therapy. Semin Liver Dis. 1999; 19(1):27-37. DOI: 10.1055/s-2007-1007095. View

Patijn G, Kay M . Hepatic gene therapy using adeno-associated virus vectors. Semin Liver Dis. 1999; 19(1):61-9. DOI: 10.1055/s-2007-1007098. View

Bueler H . Adeno-associated viral vectors for gene transfer and gene therapy. Biol Chem. 1999; 380(6):613-22. DOI: 10.1515/BC.1999.078. View

Lau J . Adeno-associated virus as a gene delivery vector for liver cells. J Hepatol. 1999; 31(2):385. DOI: 10.1016/s0168-8278(99)80244-x. View

Dienstag J, Schiff E, Wright T, Perrillo R, Hann H, Goodman Z . Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med. 1999; 341(17):1256-63. DOI: 10.1056/NEJM199910213411702. View

Melero I, Duarte M, Ruiz J, Sangro B, Galofre J, Mazzolini G . Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas. Gene Ther. 1999; 6(10):1779-84. DOI: 10.1038/sj.gt.3301010. View

Kochanek S . High-capacity adenoviral vectors for gene transfer and somatic gene therapy. Hum Gene Ther. 1999; 10(15):2451-9. DOI: 10.1089/10430349950016807. View

10.

Mazzolini G, Qian C, Xie X, Sun Y, Lasarte J, Drozdzik M . Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12. Cancer Gene Ther. 1999; 6(6):514-22. DOI: 10.1038/sj.cgt.7700072. View

11.

Clackson T . Regulated gene expression systems. Gene Ther. 2000; 7(2):120-5. DOI: 10.1038/sj.gt.3301120. View

12.

Clark K, Sferra T, Lo W, Qu G, Chen R, Johnson P . Gene transfer into the CNS using recombinant adeno-associated virus: analysis of vector DNA forms resulting in sustained expression. J Drug Target. 2000; 7(4):269-83. DOI: 10.3109/10611869909085510. View

13.

Narvaiza I, Mazzolini G, Barajas M, Duarte M, Zaratiegui M, Qian C . Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy. J Immunol. 2000; 164(6):3112-22. DOI: 10.4049/jimmunol.164.6.3112. View

14.

Aurisicchio L, DELMASTRO P, Salucci V, Paz O, Rovere P, Ciliberto G . Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis. J Virol. 2000; 74(10):4816-23. PMC: 112004. DOI: 10.1128/jvi.74.10.4816-4823.2000. View

15.

Pawlik T, Nakamura H, Yoon S, Mullen J, Chandrasekhar S, Chiocca E . Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus. Cancer Res. 2000; 60(11):2790-5. View

16.

Rogy M, Beinhauer B, Reinisch W, Huang L, Pokieser P . Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum. Hum Gene Ther. 2000; 11(12):1731-41. DOI: 10.1089/10430340050111386. View

17.

Sun Y, Peng D, Lecanda J, Schmitz V, Barajas M, Qian C . In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity. Gene Ther. 2000; 7(17):1467-76. DOI: 10.1038/sj.gt.3301264. View

18.

Grimm C, Ortmann D, Mohr L, Michalak S, Krohne T, Meckel S . Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice. Gastroenterology. 2000; 119(4):1104-12. DOI: 10.1053/gast.2000.18157. View

19.

Zeuzem S, Feinman S, Rasenack J, Heathcote E, Lai M, Gane E . Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med. 2000; 343(23):1666-72. DOI: 10.1056/NEJM200012073432301. View

20.

Barajas M, Mazzolini G, Genove G, Bilbao R, Narvaiza I, Schmitz V . Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12. Hepatology. 2000; 33(1):52-61. DOI: 10.1053/jhep.2001.20796. View