Histological and Immunological Features of Appendix in Patients with Ulcerative Colitis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2003 Mar 21

PMID 12645797

Citations 18

Authors

Yukihiko Jo

Takayuki Matsumoto

Shinichiro Yada

Shotaro Nakamura

Takashi Yao

Masayuki Hotokezaka

Ryuichi Mibu

Mitsuo Iida

Affiliations

Soon will be listed here.

Abstract

Patients with ulcerative colitis (UC) have a less frequent prior history of appendectomy than the general population. The aim of the present investigation was to elucidate histological and immunological characteristics of the appendix in UC and to assess the effect of appendectomy on the disease. Nine subjects with mildly active UC were treated by surgical appendectomy. In four subjects, the histological findings of the appendix were compatible with ulcerative appendicitis. CD3+CD4+CD25+, CD3+CD4+CD45RO+, and CD3+CD8+CD45RO+ appendiceal mononuclear cells were significantly higher in UC than in acute appendicitis and in normal appendix. There was a trend towards higher mRNA transcripts of IFN-gamma in the appendix of UC than those in other two groups. Clinical activity index decreased significantly four weeks after the appendectomy, although the effect was transient. The appendix is a site of involvement in UC, where mononuclear cells are presumed to be at a state of basal activation.

Citing Articles

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