» Articles » PMID: 12643191

Mechanisms Involved in Platelet Hyperactivation and Platelet-endothelium Interrelationships in Diabetes Mellitus

Overview
Journal Curr Diab Rep
Publisher Current Science
Specialty Endocrinology
Date 2003 Mar 20
PMID 12643191
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

This article discusses the recent findings about the mechanisms involved in platelet hyperactivation in diabetes mellitus. Particular attention is focused on the advances pertaining to 1) new features of platelet activation; 2) the role of calcium fluxes; 3) the role of glucose, insulin, and insulin resistance; 4) the role of nitric oxide; and 5) the role of endothelium.

Citing Articles

Mediation Effect of Platelet Traits on Associations of Central Obesity with Aging Biomarkers in Rural Adults of Henan, China.

Chen X, Li R, Hou X, Wang Y, Pan M, Kang N Nutrients. 2022; 14(17).

PMID: 36079858 PMC: 9460072. DOI: 10.3390/nu14173597.


Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.

Lannan K, Sahler J, Kim N, Spinelli S, Maggirwar S, Garraud O Front Immunol. 2015; 6:48.

PMID: 25762994 PMC: 4327621. DOI: 10.3389/fimmu.2015.00048.


The prothrombotic tendency in metabolic syndrome: focus on the potential mechanisms involved in impaired haemostasis and fibrinolytic balance.

Russo I Scientifica (Cairo). 2013; 2012:525374.

PMID: 24278711 PMC: 3820496. DOI: 10.6064/2012/525374.


Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome.

Smith J, Haddad E, Taylor M, Oram D, Blakemore D, Chen Q Hypertension. 2012; 59(3):719-25.

PMID: 22311905 PMC: 3418792. DOI: 10.1161/HYPERTENSIONAHA.111.181404.


The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

Spinelli S, OBrien J, Bancos S, Lehmann G, Springer D, Blumberg N PPAR Res. 2008; 2008:328172.

PMID: 18288284 PMC: 2233896. DOI: 10.1155/2008/328172.

References
1.
Seghieri G, Di Simplicio P, Anichini R, Alviggi L, De Bellis A, Bennardini F . Platelet antioxidant enzymes in insulin-dependent diabetes mellitus. Clin Chim Acta. 2001; 309(1):19-23. DOI: 10.1016/s0009-8981(01)00494-6. View

2.
Romano M, Pomilio M, Vigneri S, Falco A, Chiesa P, Chiarelli F . Endothelial perturbation in children and adolescents with type 1 diabetes: association with markers of the inflammatory reaction. Diabetes Care. 2001; 24(9):1674-8. DOI: 10.2337/diacare.24.9.1674. View

3.
Loscalzo J . Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res. 2001; 88(8):756-62. DOI: 10.1161/hh0801.089861. View

4.
Martina V, Bruno G, Zumpano E, Origlia C, Quaranta L, Pescarmona G . Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1. J Endocrinol Invest. 2001; 24(1):37-41. DOI: 10.1007/BF03343806. View

5.
Assert R, Scherk G, Bumbure A, Pirags V, Schatz H, Pfeiffer A . Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. Diabetologia. 2001; 44(2):188-95. DOI: 10.1007/s001250051598. View