Polarized Growth and Organelle Segregation in Yeast: the Tracks, Motors, and Receptors

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2003 Mar 19

PMID 12642608

Citations 72

Authors

Anthony Bretscher

Affiliations

Soon will be listed here.

Abstract

In yeast, growth and organelle segregation requires formin-dependent assembly of polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for cell growth, organelles for their segregation, and mRNA for fate determination. Several specific receptors have been identified that interact with the cargo-binding tails of the myosin Vs. A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle.

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