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Altered Enzymes in Ageing Human Fibroblasts

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Journal Nature
Specialty Science
Date 1972 Jul 7
PMID 12635262
Citations 40
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Abstract

Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.

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