Prospective Cohort Study of Comprehensive Prevention to Gastric Cancer

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2003 Mar 13

PMID 12632491

Citations 11

Authors

Hai-Qiang Guo

Peng Guan

Hai-Long Shi

Xuan Zhang

Bao-Sen Zhou

Yuan Yuan

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the preliminary effects of comprehensive prevention of gastric cancer in Zhuanghe County epidemiologically.

Methods: Stratified sampling and cluster sampling were applied to define the intervention group and the control group. The prospective cohort study was used for evaluating the effect of preventing gastric cancer. The relative risk (RR) and attributable risk percent (AR %) of intervention on gastric cancer death were calculated. Potential years of life lost (PLYY) of the disease was analyzed, and the RR and AR % of PYLL were calculated. Survival analysis was applied among the screened patients.

Results: In the first 4 years after intervening, the relative risk (RR) of intervention on death was 0.5059 (95 % CI: 0.3462-0.7392, P<0.05) with significance statistically. AR % of the intervention on death was 49.41 %. The RR of intervention on cumulative PYLL was 0.6778 (95 % CI: 0.5604-0.8198, P<0.05) with statistic significance. AR % of the intervention on cumulative PYLL was 30.32 %. The four-year survival rate of the screened patients was 0.6751 (95 % CI: 0.5298-0.9047).

Conclusion: The initiative intervention results showed that the intervention approach used in the trial was effective, it reduced mortality and increased survival rate, and alleviated the adverse effect of gastric cancer on the health and life of screened population.

Citing Articles

Epidemiology of stomach cancer.

Ilic M, Ilic I World J Gastroenterol. 2022; 28(12):1187-1203.

PMID: 35431510 PMC: 8968487. DOI: 10.3748/wjg.v28.i12.1187.

Strategies for prevention of gastrointestinal cancers in developing countries: a systematic review.

Shams A, Haug U J Glob Health. 2017; 7(2):020405.

PMID: 29250323 PMC: 5718709. DOI: 10.7189/jogh.07.020405.

The promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlying mechanisms.

Jiang Y, Yang S, Li P, Luo X, Li Z, Hao Y Oncogene. 2016; 36(9):1256-1264.

PMID: 27524415 PMC: 5340802. DOI: 10.1038/onc.2016.291.

siRNA targeting YAP gene inhibits gastric carcinoma growth and tumor metastasis in SCID mice.

Zhou Z, Zhu J, Gao C, Li L, Zhou C, Wang H Oncol Lett. 2016; 11(4):2806-2814.

PMID: 27073556 PMC: 4812121. DOI: 10.3892/ol.2016.4319.

Health economic assessment for screening of gastric cancer in a high risk population in northeastern china.

Zhou L, Guan P, Sun L, He Q, Yuan Y, Zhou B Chin J Cancer Res. 2013; 23(1):21-4.

PMID: 23467677 PMC: 3587534. DOI: 10.1007/s11670-011-0021-7.

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