The Isolated Perfused Chicken Heart As a Tool for Studying Acetylcholine Output in the Absence of Cholinesterase Inhibition

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1976 Jan 1

PMID 1262866

Citations 8

Authors

H Kilbinger

K Loffelholz

Affiliations

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Abstract

In chicken hearts, the acetylcholine (ACh) output in response to vagal stimulation was easily detectable by gas chromatography even in the absence of cholinesterase inhibition. Eserine 10(-6) M markedly increased the ACh output. In contrast, the ACh output from the perfused rabbit heart was not measurable in the absence of cholinesterase inhibition. Both ACh concentration and cholinesterase activity were higher in the chicken heart than in the rabbit heart. In conclusion, the isolated perfused chicken heart is at present a unique tool for studying the output of the parasympathetic transmitter in the absence of cholinesterase inhibition.

Citing Articles

Interstitial washout and hydrolysis of acetylcholine in the perfused heart.

LINDMAR R, Loffelholz K, Weide W Naunyn Schmiedebergs Arch Pharmacol. 1982; 318(4):295-300.

PMID: 7078663 DOI: 10.1007/BF00501168.

Evidence for bilateral vagal innervation of postganglionic parasympathetic neurons in chicken heart.

LINDMAR R, Loffelholz K, Weide W, Weis S J Neural Transm. 1983; 56(2-3):239-47.

PMID: 6864211 DOI: 10.1007/BF01243281.

Modification of vagal action on the toad heart by changes in flow.

Courtice G, McCloskey D J Comp Physiol B. 1985; 155(5):571-5.

PMID: 3939236 DOI: 10.1007/BF00694446.

The fade of the response to acetylcholine at the rabbit isolated sino-atrial node.

Boyett M, Roberts A J Physiol. 1987; 393:171-94.

PMID: 3446796 PMC: 1192388. DOI: 10.1113/jphysiol.1987.sp016818.

Acetylcholine overflow from isolated perfused hearts of various species in the absence of cholinesterase inhibition.

Dieterich H, Loffelholz K, Pompetzki H Naunyn Schmiedebergs Arch Pharmacol. 1977; 296(2):149-52.

PMID: 834314 DOI: 10.1007/BF00508467.

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