Excitatory Nature of Dopamine in the Nigro-caudate Pathway

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1976 Feb 26

PMID 1261623

Citations 16

Authors

S T Kitai

M Sugimori

J D Kocsis

Affiliations

Soon will be listed here.

Abstract

Inputs from the substantia nigra (SN) to the caudate nucleus (Cd) and the effects of electrophoretic dopamine on Cd neurones were studied in cats anaesthetized with pentobarbitone with intracellular techniques. Single shock electrical stimulation of the SN or the medial forebrain bundle (MFB) induced monosynaptic EPSPs in Cd neurones. Dopamine depolarized Cd neurones and chlorpromazine suppressed the SN or MFB induced EPSPs. Appropriate controls indicate that the drug effects were not artifactual. Some recorded neurones were identified by procion yellow dye injection as the medium-size intrinsic Cd neurones.

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