Hypoxic Neuronal Necrosis: Protein Synthesis-independent Activation of a Cell Death Program

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2003 Feb 28

PMID 12606726

Citations 26

Authors

Jerome Niquet

Roger A Baldwin

Suni G Allen

Denson G Fujikawa

Claude G Wasterlain

Affiliations

Soon will be listed here.

Abstract

Hypoxic necrosis of dentate gyrus neurons in primary culture required the activation of an orderly cell death program independent of protein synthesis. Early mitochondrial swelling and loss of the mitochondrial membrane potential were accompanied by release of cytochrome c and followed by caspase-9-dependent activation of caspase-3. Caspase-3 and -9 inhibitors reduced neuronal necrosis. Calcium directly induced cytochrome c release from isolated mitochondria. Hypoxic neuronal necrosis may be an active process in which the direct effect of hypoxia on mitochondria may lead to the final common pathway of caspase-3-mediated neuronal death.

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