Megadose Transplantation of Highly Purified Haploidentical Stem Cells: Current Results and Future Prospects

Overview

Journal Pediatr Transplant

Specialty Pediatrics

Date 2003 Feb 27

PMID 12603693

Citations 6

Authors

Rupert Handgretinger

Thomas Klingebiel

Peter Lang

Paul Gordon

Dietrich Niethammer

Affiliations

Soon will be listed here.

Abstract

The transplantation of megadoses of haploidentical hematopoietic stem cells is for a number of children with malignant or nonmalignant diseases the only curative approach. In order to prevent severe GvHD, the removal of T lymphocytes from the stem cell graft either by positive selection of CD34+ stem cells or by negative depletion of CD3+ T lymphocytes is necessary. We present the results obtained so far by CD34+ positive selection and discuss new techniques of graft engineering which might hopefully further improve the outcome of haploidentical stem cell transplantation.

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