Role of Interleukin-6 in the Control of Acute and Chronic Giardia Lamblia Infections in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Feb 22

PMID 12595478

Citations 41

Authors

Ping Zhou

Erqiu Li

Nannan Zhu

Jason Robertson

Theodore Nash

Steven M Singer

Affiliations

Soon will be listed here.

Abstract

In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.

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