A Nitrofurantoin-induced Disorder Simulating Chronic Active Hepatitis. A Case Report

Overview

Journal Acta Med Scand

Specialty General Medicine

Date 1976 Jan 1

PMID 1258704

Citations 3

Authors

B Fagrell

I Strandberg

B WENGLE

Affiliations

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Abstract

A 78-year-old woman with liver damage resembling chronic active hepatitis and occuring during long-term nitrofurantoin treatment is described. On admission to hospital she displayed jaundice, ascites and high serum levels of GOT, GPT, bilirubin and gamma-globulin as well as high titres of ANF and antibodies against smooth muscle cells. After withdrawal of nitrofurantoin the clinical and laboratory picture normalized without corticosteroid treatment, suggesting that the liver reaction was drug-induced.

Citing Articles

Autoimmune hepatitis induced by nitrofurantoin. The importance of the autoantibodies for an early diagnosis of immune disease.

Sherigar J, Fazio R, Zuang M, Arsura E Clin Pract. 2014; 2(4):e83.

PMID: 24765482 PMC: 3981194. DOI: 10.4081/cp.2012.e83.

Autoimmune hepatitis triggered by nitrofurantoin: a case series.

Appleyard S, Saraswati R, Gorard D J Med Case Rep. 2010; 4:311.

PMID: 20863377 PMC: 2955056. DOI: 10.1186/1752-1947-4-311.

Pathologic aspects of cirrhosis. A review.

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