Homeostasis in the Small Intestinal Mucosa Balanced Between Cell Proliferation and Apoptosis is Regulated Partly by the Central Nervous System

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2003 Feb 8

PMID 12572882

Citations 2

Authors

Kazuma Fujimoto

Ryuichi Iwakiri

Bin Wu

Takehiro Fujise

Seiji Tsunada

Akifumi Ootani

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate whether the central nervous system regulates mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase is a key enzyme for polyamine synthesis, which plays an important role in intestinal mucosal growth. The increase in ornithine decarboxylase activity in the duodenum just before a dark period was abolished by truncal vagotomy. An infusion of 2-deoxy-D-glucose into the third cerebroventricle activated the enzyme activity in the small intestine. Epithelial homeostasis is balanced by the regulation of cell proliferation and cell death. Intestinal mucosal apoptosis decreased in rats with ventromedial hypothalamus lesions, which induced hyperphagia and obesity. In contrast, sustained anorexia induced by 1-deoxy-D-glucosamine increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to the regulation of mucosal homeostasis in the intestinal mucosa.

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