Prenatal Genetic Testing by Amniocentesis Appears to Result in a Lower Risk of Fetal Loss Than Chorionic Villus Sampling in Singleton Pregnancies Achieved by Intracytoplasmic Sperm Injection

Objective: To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI).

Design: Retrospective analysis.

Setting: Tertiary referral center.

Patient(s): Eight hundred twenty-eight patients with singleton gestations achieved by ICSI.

Intervention(s): Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients).

Main Outcome Measure(s): Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight.

Result(s): A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 g (8.2% vs. 4.6%, respectively).

Conclusion(s): Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI.