[p27 Protein Expression and Its Significance in Human Laryngeal Carcinoma]

Objective: To determine clinical significance and expression of p27 protein in human laryngeal carcinoma tissue.

Method: To measure p27 protein expression in 50 cases laryngeal carcinoma tissue by immunohistochemical LSAB (labelled streptavidin biotin) method, 15 cases vocal cord polyps used as control.

Result: There was significant difference between p27 protein expression in laryngeal carcinoma and in vocal cord polyps, among pathological staging of laryngeal carcinoma (G1-G2 and G3), between the survived and the dead laryngeal carcinoma patients 3 years after operation, but no significant difference among clinical staging and between the patients with and without lymph node metastases. There was significant difference between the survival rate curves (Kaplan-meier curve) in p27 protein expression positive group and that in p27 protein expression negative group.

Conclusion: p27 Protein expression is related to malignant degree of laryngeal carcinoma, so it can be an important marker of identifying the malignancy and prognosis of laryngeal carcinoma.