Ets-1 Gene Expression in Patients with Thymoma

Overview

Journal Jpn J Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2003 Feb 4

PMID 12561090

Citations 2

Authors

Hidefumi Sasaki

Yoshihiro Kobayashi

Masayuki Tanahashi

Haruhiro Yukiue

Motoki Yano

Masahiro Kaji

Masanobu Kiriyama

Ichiro Fukai

Yosuke Yamakawa

Yoshitaka Fujii

Affiliations

Soon will be listed here.

Abstract

Objectives: The Ets-1 protooncogene transcription factor is involved in several cellular functions, including the activation of several proteases, and reportedly plays an important role in carcinoma invasion and metastasis. We hypothesize that Ets-1 mRNA expression could be a predictor of thymoma development and invasion.

Methods: Subjects were 37 patients with thymoma whose mRNA expression was quantified by real-time reverse-transcription polymerase chain reaction (RT-PCR) using LightCycler, a microvolume multisample fluorimeter.

Results: No significant difference was found in Ets-1 mRNA expression for gender, age, or pathological subtype. Ets-1 mRNA expression in tumor tissues from stage II-IV thymoma (25.311 +/- 42.336) was more elevated than in that from stage I thymoma (2.097 +/- 4.492) (p = 0.0374). Ets-1 mRNA expression may thus serve as a marker of higher thymoma stages.

Conclusions: With use of the Light Cycler RT-PCR assay, Ets-1 expression may play an important role in the extension and progression of thymoma as in other cancers. Further study and longer follow-up are, however, needed to confirm the Ets-1 impact on biological tumor behavior.

Citing Articles

Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.

Kar A, Gutierrez-Hartmann A Crit Rev Biochem Mol Biol. 2013; 48(6):522-43.

PMID: 24066765 PMC: 4086824. DOI: 10.3109/10409238.2013.838202.

The biology of the Ets1 proto-oncogene.

Dittmer J Mol Cancer. 2003; 2:29.

PMID: 12971829 PMC: 194255. DOI: 10.1186/1476-4598-2-29.

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