Regulation of BRCA1 Expression and Its Relationship to Sporadic Breast Cancer

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2003 Feb 1

PMID 12559046

Citations 56

Authors

Christopher R Mueller

Calvin D Roskelley

Affiliations

Soon will be listed here.

Abstract

Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression.

Citing Articles

Combined strategies with PARP inhibitors for the treatment of BRCA wide type cancer.

Xie Y, Xiao D, Li D, Peng M, Peng W, Duan H Front Oncol. 2024; 14:1441222.

PMID: 39156700 PMC: 11327142. DOI: 10.3389/fonc.2024.1441222.

Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression and its modulation by resveratrol in ER+, PR+ & triple-negative breast cancer cells.

Sahu R, Tandon S, Singh S, Das B, Hedau S BMC Cancer. 2024; 24(1):566.

PMID: 38711004 PMC: 11071212. DOI: 10.1186/s12885-024-12274-x.

A transcription-independent mechanism determines rapid periodic fluctuations of BRCA1 expression.

Nie C, Zhou X, Zhou J, Liu Z, Gu Y, Liu W EMBO J. 2023; 42(15):e111951.

PMID: 37334492 PMC: 10390875. DOI: 10.15252/embj.2022111951.

Landscape of NcRNAs involved in drug resistance of breast cancer.

Kang Y Clin Transl Oncol. 2023; 25(7):1869-1892.

PMID: 37067729 PMC: 10250522. DOI: 10.1007/s12094-023-03189-3.

Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage.

Wu X, Guo M, Cui J, Cai H, Wang S Oncogenesis. 2022; 11(1):41.

PMID: 35869059 PMC: 9307611. DOI: 10.1038/s41389-022-00417-3.

References

Troyer K, Lee D . Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network. J Mammary Gland Biol Neoplasia. 2001; 6(1):7-21. DOI: 10.1023/a:1009560330359. View

Dimitrov S, Matouskova E, Forejt J . Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. Folia Biol (Praha). 2001; 47(4):120-7. View

DiNardo D, Butcher D, Robinson D, Archer T, Rodenhiser D . Functional analysis of CpG methylation in the BRCA1 promoter region. Oncogene. 2001; 20(38):5331-40. DOI: 10.1038/sj.onc.1204697. View

Fata J, Leco K, Voura E, Yu H, Waterhouse P, Murphy G . Accelerated apoptosis in the Timp-3-deficient mammary gland. J Clin Invest. 2001; 108(6):831-41. PMC: 200934. DOI: 10.1172/JCI13171. View

Parrinello S, Lin C, Murata K, Itahana Y, Singh J, Krtolica A . Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis. J Biol Chem. 2001; 276(42):39213-9. DOI: 10.1074/jbc.M104473200. View

Atlas E, Stramwasser M, Mueller C . A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element. Oncogene. 2001; 20(48):7110-4. DOI: 10.1038/sj.onc.1204890. View

Laud K, Hornez L, Gourdou I, Belair L, Arnold A, Peyrat J . Expression of BRCA1 gene in ewe mammary epithelial cells during pregnancy: regulation by growth hormone and steroid hormones. Eur J Endocrinol. 2001; 145(6):763-70. DOI: 10.1530/eje.0.1450763. View

Ye Q, Hu Y, Zhong H, Nye A, Belmont A, Li R . BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol. 2001; 155(6):911-21. PMC: 2150890. DOI: 10.1083/jcb.200108049. View

Venkitaraman A . Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002; 108(2):171-82. DOI: 10.1016/s0092-8674(02)00615-3. View

10.

Yarden R, Pardo-Reoyo S, Sgagias M, Cowan K, Brody L . BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet. 2002; 30(3):285-9. DOI: 10.1038/ng837. View

11.

Wiseman B, Werb Z . Stromal effects on mammary gland development and breast cancer. Science. 2002; 296(5570):1046-9. PMC: 2788989. DOI: 10.1126/science.1067431. View

12.

Welcsh P, Lee M, Black D, Mahadevappa M, Swisher E, Warrington J . BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci U S A. 2002; 99(11):7560-5. PMC: 124283. DOI: 10.1073/pnas.062181799. View

13.

Talhouk R, Bissell M, Werb Z . Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol. 1992; 118(5):1271-82. PMC: 2289583. DOI: 10.1083/jcb.118.5.1271. View

14.

Sternlicht M, Lochter A, Sympson C, Huey B, Rougier J, Gray J . The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 1999; 98(2):137-46. PMC: 2853255. DOI: 10.1016/s0092-8674(00)81009-0. View

15.

Taylor J, Lymboura M, Pace P, AHern R, Desai A, Shousha S . An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer. 1998; 79(4):334-42. DOI: 10.1002/(sici)1097-0215(19980821)79:4<334::aid-ijc5>3.0.co;2-w. View

16.

Xu C, Brown M, Nicolai H, Chambers J, GRIFFITHS B, Solomon E . Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Hum Mol Genet. 1997; 6(7):1057-62. DOI: 10.1093/hmg/6.7.1057. View

17.

Xu C, Chambers J, Solomon E . Complex regulation of the BRCA1 gene. J Biol Chem. 1997; 272(34):20994-7. DOI: 10.1074/jbc.272.34.20994. View

18.

Dobrovic A, Simpfendorfer D . Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res. 1997; 57(16):3347-50. View

19.

Blackshear P, Goldsworthy S, Foley J, McAllister K, Bennett L, Collins N . Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene. 1998; 16(1):61-8. DOI: 10.1038/sj.onc.1201506. View

20.

Hennighausen L, Robinson G . Think globally, act locally: the making of a mouse mammary gland. Genes Dev. 1998; 12(4):449-55. DOI: 10.1101/gad.12.4.449. View