Cholecystectomy and the Risk for Developing Colorectal Cancer and Distal Colorectal Adenomas

Overview

Journal Br J Cancer

Specialty Oncology

Date 2003 Jan 31

PMID 12556963

Citations 33

Authors

E S Schernhammer

M F Leitzmann

D S Michaud

F E Speizer

E Giovannucci

G A Colditz

C S Fuchs

Affiliations

Soon will be listed here.

Abstract

Earlier work describes a modest association between cholecystectomy and the risk of colorectal cancer. We conducted a prospective study of 85 184 women, 36-61 years old, who had no history of cancer to evaluate whether known risk factors for colorectal cancer, including dietary history, that have not been controlled for in previous analyses can help explain the observed association. During 16 years of follow-up, 877 cases of colorectal cancer were documented and 1452 women who underwent endoscopy during the follow-up time were diagnosed with distal adenomas. After adjustment for age and other known or suspected risk factors, we found a significant, positive association between cholecystectomy and the risk of colorectal cancer (multivariate relative risk RR 1.21, 95% CI 1.01-1.46). The risk was highest for cancers of the proximal colon (RR 1.34, 95% CI 0.97-1.88) and the rectum (RR 1.58, 95% CI 1.05-2.36). However, we did not observe a significant association between cholecystectomy and distal colorectal adenomas. In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors.

Citing Articles

Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.

Fan M, Jiang Q, Cui M, Zhao M, Wang J, Lu Y World J Gastrointest Surg. 2024; 16(8):2436-2450.

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Does postcholecystectomy increase the risk of colorectal cancer?.

Dong Z, Shi R, Li P, Song X, Dong F, Zhu J Front Microbiol. 2023; 14:1194419.

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No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies.

Yu L, Liu W, Yan Y, Jiang Y, Gao X, Ruan S Int J Colorectal Dis. 2023; 38(1):179.

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Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota.

Jiang X, Jiang Z, Cheng Q, Sun W, Jiang M, Sun Y Front Med (Lausanne). 2022; 9:1000563.

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Alterations of Fungal Microbiota in Patients With Cholecystectomy.

Xu J, Ren X, Liu Y, Zhang Y, Zhang Y, Chen G Front Microbiol. 2022; 13:831947.

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